PSA: There's an easy way to beat the last two bosses! "Spoilers"
Never leave the Hookshot too far behind. You will need it throughout the game, and forgetting it in an old area can lead to tedious backtracking. Combat & Enemy Tactics
Resident Evil 0 HD Remaster is unique for its "Partner Zapping" system and its lack of traditional item boxes. This guide covers essential strategies to help you survive the Arklay Mountains. Survival & Partner Management Resident Evil 0 HD Remaster
Conserving resources is critical, as enemies can be bullet sponges.
Use Billy for combat and exploring new rooms. He has roughly 3.5x the effective health of Rebecca and deals more damage with his handgun. PSA: There's an easy way to beat the last two bosses
Since there are no item boxes, you must drop items on the floor. Dropped items appear as icons on your map. Create "supply stations" in central locations, like the Main Hall of the Training Facility.
Survival depends on knowing your characters' strengths and managing them as a team. Combat & Enemy Tactics Resident Evil 0 HD
Rebecca can mix herbs and chemicals, which Billy cannot. She also throws molotov cocktails faster.