Their most recent 2024 clash saw a combined 90 points , with the Bills outlasting the Lions 48-42 at Ford Field. Key Player Spotlight (2026 Rosters)
The Bills historically hold the upper hand in this series, which began in 1972. The Bills lead 8-4-1.
Buffalo has won four consecutive games against Detroit.
How Lions and Bills match up ahead of game of the season - ESPN
Their last meeting in Week 15 of the 2024 season was a high-scoring thriller that highlighted the parity between these cross-conference foes. Mon, Dec 16 Bills won!
The Buffalo Bills and Detroit Lions are set to continue their high-octane rivalry as they face off during the upcoming . Both teams are currently considered top-tier Super Bowl contenders, representing two of the league's most explosive offenses led by elite quarterbacks. Latest Matchup Context
Nfl Buffalo Bills Vs Detroit Lions Access
Their most recent 2024 clash saw a combined 90 points , with the Bills outlasting the Lions 48-42 at Ford Field. Key Player Spotlight (2026 Rosters)
The Bills historically hold the upper hand in this series, which began in 1972. The Bills lead 8-4-1. NFL Buffalo Bills vs Detroit Lions
Buffalo has won four consecutive games against Detroit. Their most recent 2024 clash saw a combined
How Lions and Bills match up ahead of game of the season - ESPN Buffalo has won four consecutive games against Detroit
Their last meeting in Week 15 of the 2024 season was a high-scoring thriller that highlighted the parity between these cross-conference foes. Mon, Dec 16 Bills won!
The Buffalo Bills and Detroit Lions are set to continue their high-octane rivalry as they face off during the upcoming . Both teams are currently considered top-tier Super Bowl contenders, representing two of the league's most explosive offenses led by elite quarterbacks. Latest Matchup Context