: Dysfunction in the RAR/RXR pathway can lead to the downregulation of RARβ , causing impairments in AMPA-mediated synaptic transmission and long-term potentiation (LTP).
Studies in F9 and P19 cell lines reveal complex "functional redundancies" where different types of RAR (α, β, γ) can sometimes substitute for one another: FrSi_TCRSR.part5.rar
: High glucose levels can suppress the transcriptional activity of RAR/RXR, promoting oxidative stress and cardiomyocyte apoptosis . This is linked to the phosphorylation and degradation of the receptors via the JNK pathway. : Dysfunction in the RAR/RXR pathway can lead