Strategy: Market-cap weighted, dominated by giants like Vertex, Gilead, and Amgen . Expense Ratio: 0.44% . Best for: Low-cost core exposure .

7 Best Biotech ETFs to Buy Now | Investing - U.S. News Money

Strategy: Uses a modified equal-weight index, giving smaller companies more influence . Expense Ratio: 0.35% . Best for: Conservative "buy the basket" exposure .

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Strategy: Tracks the Nasdaq Biotechnology Index at a significantly lower price point . Expense Ratio: 0.19% .

Strategy: Actively managed by Cathie Wood's team, targeting "disruptive" innovation . Expense Ratio: 0.75% . Comparison of Key Metrics 1-Year Return Expense Ratio Small/Mid-Cap Equal Weight IBB Large-Cap Market Weighted SBIO Clinical Trial Breakthroughs IBBQ Nasdaq Biotech Index Data based on recent 2026 market reports .

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The best biotech ETF to buy depends on your risk tolerance: the offers high-growth potential through an equal-weighted approach to smaller firms , while the iShares Biotechnology ETF (IBB) provides stability by focusing on large-cap industry leaders . Top Biotech ETFs to Buy Now SPDR S&P Biotech ETF (XBI) Best for: Aggressive growth and small-cap exposure .