: As these fibrous plaques calcify and thicken, the vessel diameter narrows, severely obstructing distal blood flow. ⚠️ Major Risk Factors
: Pathologically, the lesion is marked by the thinning or destructive degeneration of the tunica media. arteriosclerosis obliterans
: Chronic high blood pressure, smoking, or hyperglycemia damages the inner lining of the artery. : As these fibrous plaques calcify and thicken,
: Excess LDL ("bad") cholesterol deposits in the damaged walls, triggering inflammatory reactions. the vessel diameter narrows
The underlying mechanism of ASO is heavily tied to the biological processes of aging and lifestyle stress.