: It also refers to a recent eLife reviewed preprint (109595) that uses fruit flies to model RVCL-S , a rare genetic disease affecting blood vessels in the brain and retina.
: In both mice and humans, chronic stress was found to reprogram myeloid progenitor cells in the bone marrow. This leads to an increased production of monocytes that are more reactive to future threats. 109595
The research investigated the "priming" effect of chronic stress on the innate immune system. Traditionally, chronic stress is viewed as purely immunosuppressive (weakening the immune system), but this review-worthy study highlights a more complex mechanism where stress prepares the immune system for a hyper-responsive state. : It also refers to a recent eLife